Human macrophages secrete platelet-activating factor acetylhydrolase. A mechanism for resolution of pulmonary inflammation.

نویسندگان

  • M R Elstad
  • D M Stafforini
  • S M Prescott
  • T M McIntyre
  • G A Zimmerman
چکیده

1 Fowler AA, Hyers TM, Fisher BJ, Bechard DE, Center KM. WTebster RO. The adult respiratory distress syndrome: cell populations and soluble mediators in the airspaces of patients at high risk. Am Rev Respir Dis 1987; 136:1225-31 2 Siler TM, Swierkosz JE, Hyers TM, Fowler AA, Webster RO. Immunoreactive interleukin-1 in bronchoalveolar lavage fluid of high-risk patients and patients with the adult respiratory distress syndrome. Exp Lung Res 1989; 15:881-94 3 Kew RR, Hyers TM, Webster RO. Human C-reactive protein inhibits neutrophil chemotaxis in vitro: possible implications for the adult respiratory distress syndrome. J Lab Clin Med 1990; 115:339-45 4 Krsek-Staples JA, Kew KR, Webster RO. Altered ceruloplasmin and transferrin levels in patients with the adult respiratory distress syndrome (ARDS). FASEBJ 1989; 3:A289 5 Schosinsky KH, Lehmann HP, Beeler MF. Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine hydrochloride. Clin Chem 1974; 20:1556-63 6 Krsek-Staples J, Webster itO. Ceruloplasmin inhibits endothelial cell injury and hydroxyl radical production by phorbol myristate acetate (PMA)-stimulated neutrophils. FASEB J 1990; 4:A629 7 Zigmond SH, Hirsch JC. Leukocyte locomotion and chemotaxis: new methods for evaluation and demonstration of a cell-derived chemotactic factor. J Exp Med 1973; 137:387-410 8 Montgomery AB, Stager MA, Cat-rico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1985; 132:485-89

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Human platelets secrete the plasma type of platelet-activating factor acetylhydrolase primarily associated with microparticles.

OBJECTIVE Platelet-activating factor acetylhydrolase (PAF-AH) expresses a Ca2+-independent phospholipase A2 activity and hydrolyzes platelet-activating factor as well as oxidized phospholipids. Two major types of PAF-AH have been described: the plasma type, which is associated with lipoproteins, and the intracellular type II PAF-AH. METHODS AND RESULTS We investigated the type(s) of PAF-AH ex...

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عنوان ژورنال:
  • Chest

دوره 99 3 Suppl  شماره 

صفحات  -

تاریخ انتشار 1991