Human macrophages secrete platelet-activating factor acetylhydrolase. A mechanism for resolution of pulmonary inflammation.
نویسندگان
چکیده
1 Fowler AA, Hyers TM, Fisher BJ, Bechard DE, Center KM. WTebster RO. The adult respiratory distress syndrome: cell populations and soluble mediators in the airspaces of patients at high risk. Am Rev Respir Dis 1987; 136:1225-31 2 Siler TM, Swierkosz JE, Hyers TM, Fowler AA, Webster RO. Immunoreactive interleukin-1 in bronchoalveolar lavage fluid of high-risk patients and patients with the adult respiratory distress syndrome. Exp Lung Res 1989; 15:881-94 3 Kew RR, Hyers TM, Webster RO. Human C-reactive protein inhibits neutrophil chemotaxis in vitro: possible implications for the adult respiratory distress syndrome. J Lab Clin Med 1990; 115:339-45 4 Krsek-Staples JA, Kew KR, Webster RO. Altered ceruloplasmin and transferrin levels in patients with the adult respiratory distress syndrome (ARDS). FASEBJ 1989; 3:A289 5 Schosinsky KH, Lehmann HP, Beeler MF. Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine hydrochloride. Clin Chem 1974; 20:1556-63 6 Krsek-Staples J, Webster itO. Ceruloplasmin inhibits endothelial cell injury and hydroxyl radical production by phorbol myristate acetate (PMA)-stimulated neutrophils. FASEB J 1990; 4:A629 7 Zigmond SH, Hirsch JC. Leukocyte locomotion and chemotaxis: new methods for evaluation and demonstration of a cell-derived chemotactic factor. J Exp Med 1973; 137:387-410 8 Montgomery AB, Stager MA, Cat-rico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 1985; 132:485-89
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متن کاملDifferential expression of platelet-activating factor acetylhydrolase in lung macrophages.
Platelet-activating factor (PAF) acetylhydrolase plays a crucial role inactivating the potent inflammatory mediator, PAF. PAF is implicated in the initiation and propagation of acute lung injury. Although PAF acetylhydrolase is a constitutively active plasma protein, increased PAF production during inflammatory events may necessitate an increase in PAF acetylhydrolase activity in the local envi...
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This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated.
متن کاملHuman platelets secrete the plasma type of platelet-activating factor acetylhydrolase primarily associated with microparticles.
OBJECTIVE Platelet-activating factor acetylhydrolase (PAF-AH) expresses a Ca2+-independent phospholipase A2 activity and hydrolyzes platelet-activating factor as well as oxidized phospholipids. Two major types of PAF-AH have been described: the plasma type, which is associated with lipoproteins, and the intracellular type II PAF-AH. METHODS AND RESULTS We investigated the type(s) of PAF-AH ex...
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ورودعنوان ژورنال:
- Chest
دوره 99 3 Suppl شماره
صفحات -
تاریخ انتشار 1991